BIOMARKERS

Source: LiveScience

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Context

• A new AI-powered test could one day be used to accurately and quickly detect three major types of cancer using only a single spot of dried blood.

Details

• The new tool uses machine learning, a type of artificial intelligence (AI), to analyze by-products of metabolism, or metabolites, in blood samples.
• These metabolites — which are found in the liquid portion of blood known as serum — act as "biomarkers" that can potentially flag cancer's presence in the body

Key Findings

• Test Accuracy: The preliminary experiments indicate that the test can distinguish between patients with pancreatic, gastric, or colorectal cancer and those without cancer with high accuracy, around 82% to 100% of the time.
• Speed and Efficiency: The analysis using this new tool takes only minutes, providing rapid results compared to traditional diagnostic methods.
• Minimal Blood Requirement: The test requires less than 0.05 milliliters of dried blood, making it minimally invasive and potentially easier to administer than traditional blood tests.

Potential Impact

• Early Detection: Screening for blood biomarkers offers the potential for earlier cancer diagnosis, improving survival rates, especially for cancers like pancreatic, colorectal, and gastric, which currently lack standalone blood tests.
• Global Access: The use of dried blood samples could democratize cancer screening by improving access to testing, particularly in remote or resource-limited areas.
• Reducing Undiagnosed Cases: The test could significantly reduce the proportion of undiagnosed cases of these cancers if implemented in large-scale screening programs.

About Biomarkers

• Biomarkers are measurable indicators of biological processes, conditions, or responses to interventions.
• They can be molecular, biochemical, physiological, or imaging-based characteristics that can be objectively measured and evaluated.

Types of Biomarkers:

• Genetic Biomarkers: These biomarkers involve variations in an individual's DNA sequence and can indicate susceptibility to certain diseases or predict treatment response.
• Protein Biomarkers: Proteins such as enzymes, hormones, or antibodies can serve as biomarkers, reflecting various physiological states or disease conditions.
• Metabolic Biomarkers: These biomarkers represent the products of metabolic processes and can indicate the presence or progression of diseases like diabetes or metabolic syndrome.
• Imaging Biomarkers: Imaging techniques like MRI, CT scans, or PET scans can reveal structural or functional changes in tissues or organs, serving as biomarkers for disease diagnosis or monitoring.
• Epigenetic Biomarkers: Changes in gene expression patterns due to modifications in DNA or histone proteins can serve as epigenetic biomarkers, offering insights into disease mechanisms or environmental exposures.

Significance of Biomarkers:

• Disease Diagnosis: Biomarkers facilitate early detection and diagnosis of diseases, enabling timely interventions and improved patient outcomes.
• Prognosis: Certain biomarkers can predict disease progression, treatment response, and patient survival rates, aiding clinicians in tailoring personalized treatment plans.
• Monitoring Treatment Efficacy: Biomarkers help monitor the effectiveness of therapeutic interventions, allowing adjustments in treatment strategies as needed.
• Drug Development: Biomarkers play a crucial role in drug discovery and development by identifying potential therapeutic targets, predicting drug responses, and stratifying patient populations for clinical trials.
• Precision Medicine: Biomarker-based approaches support the concept of precision medicine by enabling targeted therapies based on individual genetic, molecular, or phenotypic characteristics.

Applications of Biomarkers:

• Cancer Diagnosis and Management: Biomarkers such as tumor-specific antigens, genetic mutations, or circulating tumor cells are used for cancer detection, staging, and monitoring treatment response.
• Cardiovascular Disease Risk Assessment: Biomarkers like cholesterol levels, C-reactive protein, or cardiac troponins help assess cardiovascular risk and guide preventive strategies.
• Neurological Disorders: Biomarkers such as amyloid-beta and tau proteins are used in the diagnosis and monitoring of neurodegenerative diseases like Alzheimer's.
• Infectious Diseases: Biomarkers such as viral RNA or specific antibodies aid in the diagnosis and management of infectious diseases like HIV/AIDS or hepatitis.
• Personalized Medicine: Biomarker-based approaches enable personalized treatment regimens tailored to an individual's genetic makeup, disease subtype, or treatment response.

Challenges:

• Biomarker discovery requires rigorous validation to ensure reliability and reproducibility across different populations and clinical settings.
• Biological variability and disease heterogeneity pose challenges in identifying universal biomarkers applicable to diverse patient populations.
• Ethical issues related to patient privacy, informed consent, and data sharing must be addressed, along with regulatory requirements for biomarker development and clinical use.
• Advancements in technology are needed to enhance the sensitivity, specificity, and cost-effectiveness of biomarker detection methods.
• Integrating data from genomics, proteomics, metabolomics, and other omics disciplines requires sophisticated bioinformatics tools and interdisciplinary collaboration.

Must read articles:

Cancer

Sources:

LiveScience

PRACTICE QUESTION Q.  Discuss the significance of biomarkers in modern healthcare, highlighting their role in disease diagnosis, prognosis, and personalized medicine. (250 words)