DBT-National Institute of Biomedical Genomics (NIBMG), Kalyani has created a database of genomic variations in oral cancer; the first of its kind in the world.
NIBMG has made this database publicly-accessible.
About
dbGENVOC is a browsable online database of GENomic Variants of Oral Cancer and is a free resource.
First release of dbGENVOC contains
~24 million somatic and germline variants derived from whole exome sequences of 100 Indian oral cancer patients and whole genome sequences of 5 oral cancer patients from India,
somatic variation data from 220 patient samples drawn from the USA and analyzed by TCGA-HNSCC project and
Manually curated variation data of 118 patients from recently published peer-reviewed publications.
Oral cancer is the most prevalent form of cancer among men in India, largely fuelled by tobacco-chewing.
Tobacco-chewing causes changes in the genetic material of cells in the oral cavity. These changes (mutations) precipitate oral cancer.